G/A1947 polymorphism in catechol‐O‐methyltransferase (COMT) gene in Parkinson's disease
Identifieur interne : 005345 ( Main/Exploration ); précédent : 005344; suivant : 005346G/A1947 polymorphism in catechol‐O‐methyltransferase (COMT) gene in Parkinson's disease
Auteurs : T. Xie [Hong Kong] ; Ho [Hong Kong] ; L. S. W. Li [Hong Kong] ; O. C. K. Ma [Hong Kong]Source :
- Movement Disorders [ 0885-3185 ] ; 1997-05.
English descriptors
- KwdEn :
- Aged, Alleles, Base Sequence, Catechol O-Methyltransferase (genetics), Catechol O-Methyltransferase (metabolism), Catechol‐O‐methyltransferase, DNA Primers, Female, Humans, Male, Methionine (genetics), Middle Aged, Molecular Sequence Data, Parkinson Disease (enzymology), Parkinson Disease (genetics), Parkinson's disease, Polymerase Chain Reaction, Polymorphism, Polymorphism, Genetic, Valine (genetics).
- MESH :
- chemical , genetics : Catechol O-Methyltransferase, Methionine, Valine.
- chemical , metabolism : Catechol O-Methyltransferase.
- enzymology : Parkinson Disease.
- genetics : Parkinson Disease.
- Aged, Alleles, Base Sequence, DNA Primers, Female, Humans, Male, Middle Aged, Molecular Sequence Data, Polymerase Chain Reaction, Polymorphism, Genetic.
Abstract
High and low catechol‐O‐methyltransferase (COMT) activity is significantly determined by thermostability, which is caused by a valine/methionine108 polymorphism associated with polymorphic G/A1947 bases, in exon 4 of the COMT gene. Our allelic association study on this polymorphism did not find any statistically significant difference between our Chinese Parkinson's disease and that of control subjects. These results show that this polymorphism and hence the thermostability of COMT enzyme are not related to a risk of developing Parkinson's disease.
Url:
DOI: 10.1002/mds.870120325
Affiliations:
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Xie</name><affiliation wicri:level="1"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>University Department of Medicine, University of Hong Kong, Queen Mary Hospital</wicri:regionArea><wicri:noRegion>Queen Mary Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Ho" sort="Ho" uniqKey="Ho" last="Ho">Ho</name><affiliation wicri:level="1"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>University Department of Medicine, University of Hong Kong, Queen Mary Hospital</wicri:regionArea><wicri:noRegion>Queen Mary Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Li, L S W" sort="Li, L S W" uniqKey="Li L" first="L. S. W." last="Li">L. S. W. Li</name><affiliation wicri:level="1"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>University Department of Medicine, University of Hong Kong, Queen Mary Hospital</wicri:regionArea><wicri:noRegion>Queen Mary Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Ma, O C K" sort="Ma, O C K" uniqKey="Ma O" first="O. C. K." last="Ma">O. C. K. Ma</name><affiliation wicri:level="1"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Clinical Biochemistry Unit, University of Hong Kong, Queen Mary Hospital</wicri:regionArea><wicri:noRegion>Queen Mary Hospital</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1997-05">1997-05</date><biblScope unit="vol">12</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="426">426</biblScope><biblScope unit="page" to="427">427</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">BC0DD0605A1CFA6157C02D096490A1A18D67D658</idno><idno type="DOI">10.1002/mds.870120325</idno><idno type="ArticleID">MDS870120325</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alleles</term><term>Base Sequence</term><term>Catechol O-Methyltransferase (genetics)</term><term>Catechol O-Methyltransferase (metabolism)</term><term>Catechol‐O‐methyltransferase</term><term>DNA Primers</term><term>Female</term><term>Humans</term><term>Male</term><term>Methionine (genetics)</term><term>Middle Aged</term><term>Molecular Sequence Data</term><term>Parkinson Disease (enzymology)</term><term>Parkinson Disease (genetics)</term><term>Parkinson's disease</term><term>Polymerase Chain Reaction</term><term>Polymorphism</term><term>Polymorphism, Genetic</term><term>Valine (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Catechol O-Methyltransferase</term><term>Methionine</term><term>Valine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Catechol O-Methyltransferase</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Alleles</term><term>Base Sequence</term><term>DNA Primers</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Molecular Sequence Data</term><term>Polymerase Chain Reaction</term><term>Polymorphism, Genetic</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High and low catechol‐O‐methyltransferase (COMT) activity is significantly determined by thermostability, which is caused by a valine/methionine108 polymorphism associated with polymorphic G/A1947 bases, in exon 4 of the COMT gene. Our allelic association study on this polymorphism did not find any statistically significant difference between our Chinese Parkinson's disease and that of control subjects. These results show that this polymorphism and hence the thermostability of COMT enzyme are not related to a risk of developing Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Hong Kong</li></country></list><tree><country name="Hong Kong"><noRegion><name sortKey="Xie, T" sort="Xie, T" uniqKey="Xie T" first="T." last="Xie">T. Xie</name></noRegion><name sortKey="Ho" sort="Ho" uniqKey="Ho" last="Ho">Ho</name><name sortKey="Li, L S W" sort="Li, L S W" uniqKey="Li L" first="L. S. W." last="Li">L. S. W. Li</name><name sortKey="Ma, O C K" sort="Ma, O C K" uniqKey="Ma O" first="O. C. K." last="Ma">O. C. K. Ma</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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